These are the two heavyweight weight-loss shots: Wegovy at 14.9% average weight loss and Zepbound at up to 22.5%. The 7-point gap is real, and it has a hidden cost: bigger, faster weight loss pulls more muscle with it unless protein is protected. On Zepbound, the protein rule stops being advice and becomes the diet.
| A | B | |
|---|---|---|
| Active ingredient | Semaglutide | Tirzepatide |
| Average weight loss | 14.9% (STEP 1) | Up to 22.5% (SURMOUNT-1) |
| Dosing | Weekly | Weekly |
| Muscle-loss risk | Significant | Higher — more total loss |
| Protein priority | High | Highest |
The same judgment framework runs across this site — protein, fiber and how heavy a food sits on a slow stomach.
| Easy on both | Risky on both |
|---|---|
|
|
For weight loss, Zepbound by a clear margin (up to 22.5% vs 14.9%). For tolerability and muscle preservation, the advantage narrows — the bigger loss demands better protein discipline.
Effectively, yes. The protein target (1.2-1.6 g/kg/day) is the same on paper, but the stakes are higher because the total weight loss is larger.
Yes — the food framework is identical. Lean protein, vegetables, legumes and whole grains are safe on both; fried food and sugary drinks are risky on both.
This comparison presents published trial data (STEP, SURMOUNT, SCALE, OASIS 4) and FDA label information for reference. It is not medical advice and does not recommend any medication. Prescription decisions belong to you and your healthcare provider.